Spoligotyping, genotyping, and spatial distribution of Mycobacterium bovis in cattle in the state of Bahia, Brazil

ABSTRACT: Mycobacterium bovis is responsible for bovine and buffalo tuberculosis, an important zoonotic disease with global distribution. The knowledge of the distribution precise identification this disease, including advanced diagnoses such as spoligotyping, allows choosing best strategies to fight disease’s progress. present work aimed investigate mycobacteria’s presence, genotype their strains, evaluate tuberculosis cases’ spatial from suggestive lesions in carcasses inspected slaughterhouses under official inspection regime state Bahia, Brazil. study investigated 453,417 animals. Among these, 31 (0.007%) 17 municipalities were suspected tuberculosis. culture medium growth, 95% these categorized alcohol-acid resistant bacilli (BAAR). All isolates subjected spoligotyping confirmed M. (SB0120, SB0121, SB0852, SB0828, SB0295, SB0881, SB1648, SB6119, SB0140, SB1055). strain SB0120 was most prevalent, profile has been described cases human by bovis, highlighting potential profile. This also identified strains never reported a distinctive pattern other parts Brazil, besides mixed infections. Besides, identify before state, Brazil (SB6119 respectively). An unpublished inserted international database (Mbovis.org), named SB2715.